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Dates are subject to change as adjustments are expected to accommodate television partners' requests. Television selections for the first three weeks of the season and special dates are due to the Conference by July 1.
| Week | Baylor | Iowa State | Kansas | Kansas State | Oklahoma |
| Aug. 31 | Northern Iowa | North Dakota State | La-Monroe | ||
| Sept. 7 | Buffalo | South Dakota | La-Lafayette | West Virginia | |
| Sept. 14 | at SMU | Iowa | at Rice | UMass | Tulsa |
| Sept. 21 | La-Monroe | at Tulsa | Louisiana Tech | at Texas | |
| Sept. 28 | at Notre Dame | ||||
| Oct. 5 | West Virginia | Texas * | Texas Tech | at Oklahoma State | TCU |
| Oct. 12 | at Kansas State | at Texas Tech | at TCU | Baylor | vs. Texas ~ |
| Oct. 19 | Iowa State | at Baylor | Oklahoma | at Kansas | |
| Oct. 26 | at Kansas | Oklahoma State | Baylor | West Virginia | Texas Tech |
| Nov. 2 | at Kansas State | at Texas | Iowa State | ||
| Nov. 9 | Oklahoma | TCU | at Oklahoma State | at Texas Tech | at Baylor |
| Nov. 16 | vs. Texas Tech | at Oklahoma | West Virginia | TCU | Iowa State |
| Nov. 23 | at Oklahoma State | Kansas | at Iowa State | Oklahoma | at Kansas State |
| Nov. 30 | at TCU | at West Virginia ** | Kansas State | at Kansas | |
| Dec. 7 | Texas | at Oklahoma State | |||
| Week | Oklahoma State | TCU | Texas | Texas Tech | West Virginia |
| Aug. 31 | vs. Mississippi St. % | vs. LSU # | New Mexico State | at SMU | William & Mary |
| Sept. 7 | at UT San Antonio | SE Louisiana | at BYU | SF Austin | at Oklahoma |
| Sept. 14 | Lamar | at Texas Tech | Ole Miss | TCU | Georgia State |
| Sept. 21 | Kansas State | Texas State | vs. Maryland + | ||
| Sept. 28 | at West Virginia | SMU | Oklahoma State | ||
| Oct. 5 | Kansas State | at Oklahoma | at Iowa State * | at Kansas | at Baylor |
| Oct. 12 | Kansas | vs. Oklahoma ~ | Iowa State | ||
| Oct. 19 | TCU | at Oklahoma State | at West Virginia | Texas Tech | |
| Oct. 26 | at Iowa State | Texas | at TCU | at Oklahoma | at Kansas State |
| Nov. 2 | at Texas Tech | West Virginia | Kansas | Oklahoma State | at TCU |
| Nov. 9 | Kansas | at Iowa State | at West Virginia | Kansas State | Texas |
| Nov. 16 | at Texas | at Kansas State | Oklahoma State | vs. Baylor | at Kansas |
| Nov. 23 | Baylor | ||||
| Nov. 30 | Baylor | Texas Tech (11/28) | at Texas (11/28) | Iowa State ** | |
| Dec. 7 | Oklahoma | at Baylor | |||
* Could be played on Thursday, October 3
** Could be played on Friday, November 29
% Played in Reliant Stadium - Houston, Texas
# Played in Cowboys Stadium - Arlington, Texas
+ Played in Ravens Stadium - Baltimore, Maryland
~ Played in Cotton Bowl - Dallas, Texas
