Franklin rushed for a career-best 152 yards with two touchdowns to help the Tigers (6-5, 4-4 Big 12) overcome Henry Josey's season-ending knee injury last week. He was 13 for 20 for 172 yards and two more touchdowns, including a 7-yarder to Marcus Lucas earlier in the fourth that cut Texas Tech's lead to three.
Texas Tech threatened late, driving to the Missouri 6, before Dominique Hamilton tipped a pass from Seth Doege and Michael Sam intercepted at the 4.
Doege threw for one touchdown and ran for another for Texas Tech (5-6, 2-6), which has lost four in a row and must beat Baylor next week to become bowl eligible for the 12th straight season.
This was a major improvement for the Red Raiders, who were whipped by an average of 42 points the previous three games and absorbed the worst loss in school history last week in a 66-6 rout against Oklahoma State.
Pinkel can rejoin the team Thursday, two days ahead of the season finale against Kansas in Kansas City. Fans in midfield seats across from the Missouri sideline unfurled a banner that read ``We (Love) You, Gary.''
Pinkel's wife, Vickie, attended the game.
Missouri trailed entering the fourth quarter for the seventh time, and won for the second time under those circumstances.
A week after trailing 49-0 at halftime in a 66-6 loss to Oklahoma State, Texas Tech started fast, playing with the wind on a gusty day, and led 17-10 at the break, fueled by touchdowns on two of the first three possessions - a 1-yard run by Bradley Marquez out of the wildcat formation and Doege's 3-yard run. It was only the third time Tech had led at the break all season.
Michael Egnew's first touchdown catch in five games came on a leaping grab in the back of the end zone to cut Missouri's deficit to 20-17 with 4:43 to go in the third quarter. It was the first touchdown in the third quarter in five games for the Tigers, who have totaled 40 points in that quarter all year.
Texas Tech went up 10 again on Darrin Moore's 24-yard catch from Doege with one second left in the third that made it 27-17.
The wind was such a factor early that Texas Tech called a timeout to force Missouri to punt into it. The move was foiled when Trey Barrow got a very favorable roll on a 68-yarder into the end zone.
Missouri blew a scoring chance in the first quarter when Kendial Lawrence got stripped by Cornelius Douglas at the Red Raiders 6-yard line and fumbled the ball out of the end zone.
Moore's 54-yard run to the 6 topped his season total of 39 yards the first 10 games and set up a 5-yard run by Franklin that capped a 10-play, 90-yard drive, the Tigers' longest of the year.
Missouri cornerback E.J. Gaines had two pass breakups for a season total of 16, breaking the single-season school record set by Michael Harden in 2002.